CIRCA Therapeutics is developing ligand-directed targeted protein degraders to address high-value oncology targets. We combine computational design, medicinal chemistry, and translational biology to advance differentiated candidates.


We develop ligand-directed targeted protein degraders for oncology programs.Computational design to inform warhead and linker selection.Medicinal chemistry to synthesize and optimize candidate series.In vitro biology and mechanistic assays to validate degradation and selectivity.Translational strategy to prioritize programs with clear path to development.

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